ADAM17 2:9488486-9556732

Reverse strand gene: ADAM metallopeptidase domain 17

Formerly known as: TACE

Also known as: CD156B, cSVP, ENSG00000151694

Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface … Source: UniProt

DECIPHER holds no open-access sequence variants in this gene